CELSIOR COLD FLUSH STORAGE AND TRANSPORT SOLUTION FOR HEARTS
A Cardiac Preservation Solution Related Image
(Not Necessarily related to the device)Description:
CELSIOR COLD FLUSH STORAGE AND TRANSPORT SOLUTION FOR HEARTS by SANGSTAT MEDICAL CORP.
The CELSIOR Cold Flush Storage and Transport Solution is a superior product introduced by the renowned SangStat Medical Corp. This high-quality solution is primarily designed for the storage and transportation of hearts for transplantation. Its primary aim is to minimize myocardial damage during the vulnerable window of organ retrieval and transplantation.
One of the essential attributes of CELSIOR is its unique ability to decrease ischemic injury or cell death during the crucial ischemic period. This is possible thanks to its optimal formulation, composed of necessary electrolytes, impermeants, colloid, buffer system, and free radical scavenger. When compared with other preservation solutions, CELSIOR has demonstrated a reduced rate of primary graft failure in several clinical studies.
It is preeminent for preserving the metabolic functioning integrity of the myocardial cells during the acute phase of hypothermia. The CELSIOR solution also significantly inhibits the destruction of endothelial cells - a common occurrence when organs are preserved with other solutions. This unique property of CELSIOR contributes to the maintenance of the endothelial integrity of the cardiac microvasculature, ultimately leading to better post-retransplantation outcomes.
In summary, the CELSIOR Cold Flush Storage and Transport Solution offers a reliable and technologically advanced choice for heart storage and transport for transplantation procedures, offering benefits both in terms of preserving organ integrity and improving patient outcomes.
Primary Use:
The CELSIOR Cold Flush Storage and Transport Solution for Hearts is a device primarily utilized within cardiovascular surgery and transplantation procedures. Its main purpose is to preserve harvested hearts by maintaining organ viability and functionality during the period between procurement and transplantation. The CELSIOR solution works by lowering the temperature of the organ in a controlled manner which, in turn, slows down metabolic processes and minimizes the risk of tissue damage. This critical interval of cold storage allows the organ to be safely transported and properly prepared for the recipient, thus ensuring a higher success rate for heart transplants. Robust and scientifically validated, CELSIOR is a testament to continuous advances in the field of transplant medicine
How It Works:
Introduction to CELSIOR Cold Flush Storage and Transplant Solution for Hearts
CELSIOR is a globally recognized and acclaimed cold flush storage and transport solution, specifically designed for preserving the integrity and viability of hearts that have been removed for the purpose of transplantation. The formula is crafted meticulously with a focus on cardiovascular tissues, ensuring optimal protection during the crucial period from organ procurement to transplantation.Functioning of CELSIOR Cold Flush Storage and Transport Solution for Hearts
Upon the procurement of the organ, the CELSIOR solution is introduced into the coronary circulation of the heart. This is typically achieved by canulating the aorta and applying a high-pressure cold perfusion method. The temperature of the solution used is typically between 2-4°C.The initial role of the solution is to rapidly cool the heart in order to minimize metabolic activity and oxygen consumption. The flush also reduces the risk of ischemic damage (damage due to lack of oxygen and nutrients) to the heart. The goal of this initial flush is to slow down any potential decay resulting from the inevitable warm ischemic time, where the organ is disconnected from any blood supply at body temperature.
Once the heart is perfused with the solution and its temperature has been lowered, it is then stored in the solution and ready for transportation. This process allows the heart to remain in a state of suspended animation, reducing the need for oxygen and minimizing cell damage during the transport period.
Components and their Role
The CELSIOR solution is made up of various components that each play a vital role in preserving the organ's integrity. These include: 1. Ions: Sodium, Potassium, Magnesium, and Chloride ions maintain and stabilize the electrical activity within the heart cells, preventing abnormal heart rhythms or arrhythmias.2. Glutathione: A potent antioxidant that aids in mitigating damage from oxidative stress.
3. Mannitol: An osmotic diuretic that helps to decrease cellular swelling, which can occur due to ischemic injury.
4. Lactobionate: It aids in preventing cellular edema and maintains the acid-base balance.
5. Histidine: It buffers the acidity that could result from the lack of oxygen, helping to maintain pH balance within the cells.
All these constituents work synergistically, making CELSIOR the solution of choice for many clinicians in the realm of cardiac transplantation. It showcases a balance of electrolyte and osmotic agents, antioxidants, and pH buffers that ensure the heart's optimal preservation during the journey from donor to recipient.
Manufacturer:
SANGSTAT MEDICAL CORP.
Status: In Stock
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